“To eat or not to eat”: how does food impact drug efficacy?

Thursday 1 October 2015
12:30-14:00
B3*     Session accredited under ACPE, UAN: 0579-0000-15-007-L04-P (1.5 contact hours)

Organised by the FIP Programme Committee

Introduction

The majority of drug products are intended for oral administration where drug absorption is facilitated by various mechanisms physiologically designed for nutrient uptake. Clinical evaluation of drug absorption in the presence and absence of food has identified specific food-drug interactions that significantly affect oral bioavailability. Pharmacists skilled in scientific concepts underlying food-drug interactions have an opportunity to augment patient-centred counselling and, overall, enhance the outcome of drug management. The focus of this interactive discussion session is to facilitate comprehensive scientific interpretation of food-drug interactions for pharmacists.

Learning objectives

Knowledge-based session

At the conclusion of this session, participants will be able to:

  1. List positive and negative consequences of food-drug interactions on oral absorption.
  2. Explain the effect of high fat meals on oral bioavailability of drugs with low aqueous solubility.
  3. Distinguish clinically relevant alterations in drug absorption induced by nutrients.
  4. Defend the importance of food-drug interaction counselling for effective drug management.

Chairs: Giovanni Pauletti (University of Cincinnati, USA) and Hiroshi Suzuki (University of Tokyo, Japan)

Programme

12:30 1) Effect of food on clinical drug efficacy
Abdul Basit (University College of London, UK)

13:00 2) Solubility-enhancing consequences induced by food components
Giovanni Pauletti (University of Cincinnati, USA)

13:30 3) Variability in oral bioavailability and lymphatic transport of poorly water soluble, lipophilic drugs
Natalie Trevaskis (Monash University, Australia)