Reducing inter-individual variability: the power of a practitioner/scientist team approach

Thursday 1 October 2015
14:30-17:30
B2*     Session accredited under ACPE, UAN: 0579-0000-15-006-L04-P (3.0 contact hours)

Organised by the FIP Programme Committee

Introduction

Variable responses of patients to fixed dose drug interventions challenge pharmacists in formulating the most effective medication treatment plan. To effectively overcome this limitation, team-based approaches jointly involving practitioners and pharmaceutical scientists have identified genetic and non-genetic causes underlying inter-individual variability in clearance and bioavailability. This session centers on non-genetic factors contributing to substantial inter-individual variability in oral bioavailability and how scientific exploration of these clinically relevant cases documented by practitioners ultimately resulted in improved management of patients. 

Learning objectives

Knowledge-based session

At the conclusion of this session, participants will be able to:

  1. Describe the contribution of intestinal transporters to inter-individual variability in oral bioavailability.
  2. Define pharmacokinetic approaches to delineate non-genetic causes underlying inter-individual variability in oral bioavailability.
  3. Analyse the impact of comorbidities on transporter-mediated inter-individual variability in oral bioavailability.
  4. Detect the value of pharmacists documenting inter-individual variability in pharmacokinetic behaviour of drugs.

Chairs: Giovanni Pauletti (University of Cincinnati, USA) and Hiroshi Suzuki (University of Tokyo, Japan)

Programme

14:30 1) Introduction by the Chair

14:35 2) Current status of personalised platelet inhibitor treatment in cardiology
Dietmar Trenk (University of Freiburg, Germany)

15:10 3) Effect of gastrointestinal surgery on oral absorption
Trevor Johnson (Certara, UK)

15:45 Break

16:00 4) Impact of lymphatic transport on post-prandial oral bioavailability
Natalie Trevaskis (Monash University, Australia)

16:35 5) Novel strategies for reducing inter-individual variability in oral absorption
Giovanni Pauletti (University of Cincinnati, USA)

17:10 6) Panel discussion