“Getting personal”: pharmacogenomics at the crossroads of practice and science

Thursday 1 October 2015
09:00-12:00
B1*     Session accredited under ACPE, UAN: 0579-0000-15-005-L04-P (3.0 contact hours)

Organised by the FIP Programme Committee

Introduction

Scientific advances in the understanding of how genes impact a patient’s response to medicines offer new exciting opportunities for clinical implementation of personalised medicine approaches by practicing pharmacists. To further delineate clinically relevant consequences of genetic variations, pharmacists must embrace their important role as educator, recorder, and communicator of medication-associated responders and non-responders. Synergistic interactions between pharmacists and basic scientists such as geneticists and pharmacologists who focus on pharmacogenomic analysis is predicted to form the basis for novel evidence of personalised medicine strategies that will increase the value of therapeutic interventions for patients in the future.

Learning objectives

Knowledge-based session

At the conclusion of this session, participants will be able to:

  1. Describe how genetic variations impact the efficacy of molecular targeted drugs.
  2. Identify inter-individual differences in efficacy of drug interventions.
  3. Explain the concept of implementing personalised medicine strategies based on genetic variations.
  4. Distinguish the value of pharmacists participating in the development of novel personalized medicine strategies.

Chairs: Giovanni Pauletti (University of Cincinnati, USA) and Hiroshi Suzuki (University of Tokyo, Japan)

Programme

09:00 1) Introduction by the Chair

09:05 2) Pharmacogenomics: from discovery to clinical practice
Julie Johnson (University of Florida, USA)

09:45 3) Clinical manifestations of relevant inter-individual differences in drug response
Katsushi Tokunaga (University of Tokyo, Japan)

10:25 Break

10:40 4) The genetic, cellular and molecular basis of idiosyncratic drug toxicity
Kevin Park (Institute of Translational Medicine at the University of Liverpool, UK)

11:20 5) Diagnostic tools to effectively implement personalised medicine strategies
Mariangela Russo (Institute of Cancer Research and Treatment, Italy)